Thursday, December 4, 2008

Medical News Today News Alert

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** BREAST CANCER News **

Novel Basis Identified For Tamoxifen Failure
http://www.medicalnewstoday.com/articles/131800.php
Tamoxifen may worsen breast cancer in a small subset of patients. Research published in BioMed Central's open access journal <i>Breast Cancer Research</i> suggests that in patients who show reduced or absent expression of the protein E-cadherin, commonly used anti-oestrogen drugs such as tamoxifen may promote more harmful cancer cell behaviour.

Breast Radiation Exposure Reduced By 50 Percent Using Angled Gantry Technique
http://www.medicalnewstoday.com/articles/131789.php
A novel angled gantry approach to coronary CT angiography reduced radiation exposure to the breast by more than 50%, according to Thomas Jefferson University researchers.Ethan Halpern, M.D., associate professor of Radiology at Jefferson Medical College of Thomas Jefferson University in Philadelphia, presented the research at the 94th Scientific Assembly and Annual Meeting of the Radiological Society of North America.

Molecular Breast Imaging Identifies Occult Cancer
http://www.medicalnewstoday.com/articles/131708.php
Breast-Specific Gamma Imaging (BSGI) is shown to be an effective method of identifying mammographically and clinically occult (hidden) breast cancer. BSGI is a molecular breast imaging technique that can see lesions independent of tissue density and discover very early stage cancers.

New Breast Imaging Technology Targets Hard To Detect Cancers
http://www.medicalnewstoday.com/articles/131705.php
Breast-specific gamma imaging (BSGI) is effective in the detection of cancers not found on mammograms or by clinical exam, according to a study presented at the annual meeting of the Radiological Society of North America (RSNA).

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** CANCER / ONCOLOGY News **

Discovery Of New Enzyme In Cancer Growth May Explain Why Cancer Grows; Spreads
http://www.medicalnewstoday.com/articles/131821.php
While studying the mechanics of blood clots, researchers at the University of Oklahoma Health Sciences Center discovered a new enzyme that not only affects the blood, but seems to play a primary role in how cancer tumors expand and spread throughout the body.

Best Treatments For Long-Term Survival In Brain Tumor Patients Identified By Mayo Clinic
http://www.medicalnewstoday.com/articles/131819.php
A new Mayo Clinic study found that patients with low-grade gliomas survived longest when they underwent aggressive surgeries to successfully remove the entire tumor. If safely removing the entire tumor was not possible, patients survived significantly longer when surgery was followed by radiation therapy.

New Criteria Identify Additional Patients With Cancer Who Benefit From Liver Transplantation
http://www.medicalnewstoday.com/articles/131811.php
A substantial number of patients with hepatocellular carcinoma (HCC) who exceed the Milan criteria (which are currently used to select transplant candidates) could also be good candidates for successful transplantation, according to findings of a web-based survey of 1112 patients, which is published in an Article early Online and in the January edition of <i>The Lancet Oncology.

Plasmid IL-12 And Electroporation Combination Against Metastatic Melanoma Achieves Systemic Response
http://www.medicalnewstoday.com/articles/131808.php
Inovio Biomedical Corporation (AMEX:INO), a leader in enabling the development of DNA vaccines using electroporation-based DNA delivery, announced today the final results of a Phase I clinical study demonstrating safe and effective treatment of metastatic melanoma in the first-in-man trial of a DNA-based therapy designed to express a therapeutic protein through in vivo delivery using electroporation.

ASTRO Publications Garner Three MarCom Awards
http://www.medicalnewstoday.com/articles/131804.php
The American Society for Therapeutic Radiology and Oncology has received three 2008 MarCom Awards for its work on its 2008 Annual Report, <i>ASTROnews and The Radiation Oncology Treatment Team</i> brochure.

NHS Top-Up System Has Hidden Costs That Have Not Been Accounted For, UK
http://www.medicalnewstoday.com/articles/131796.php
The "cost" of top-up payments to the NHS are not confined to the cost of the drug and require the NHS to make some long overdue changes or risk financial failure, argue two editorials published in <i>Clinical Oncology</i>, by Elsevier.

Bowel Cancer Screening Programme Launched
http://www.medicalnewstoday.com/articles/131785.php
University Hospitals Bristol NHS Foundation Trust (UH Bristol) is delighted to announce that the life saving NHS Bowel Screening Programme was launched in the Bristol and Weston area from Monday (1 December 2008).

Award-Winning Oncologist Leads New Advancement In Personalized Medicine
http://www.medicalnewstoday.com/articles/131783.php
After hearing the words, "you've got cancer," most patients are given a drug or combination of agents according to guidelines or standards of care. These treatments, in the oncologist's best judgment, are considered most likely to work based on the results of clinical studies in patients with similar tumor types.

Race, Ethnicity Likely Affects Emotional Well-Being Of Cancer Patients, Study Finds
http://www.medicalnewstoday.com/articles/131777.php
Black cancer patients report having poorer physical and social well-being than their white counterparts but better emotional well-being, according to a study published in the November issue of the <cite>Journal of Pain and Symptom Management</cite>, <a href="http://www.

Cancer Mortality Rate Declines Are Promising, But More Needs To Be Done, Editorial States
http://www.medicalnewstoday.com/articles/131765.php
The latest annual <a href="http://www.kaisernetwork.org/daily_reports/rep_index.cfm?hint=3&DR_ID=55780" target="_new">report</a> on cancer trends shows "that a long-term decline in death rates has continued for both sexes," and there "seems little doubt that the decline in cancer death rates since the early 1990s is real," a <a href="http://www.

Tumor Causing Cells Are Common In Some Cancers
http://www.medicalnewstoday.com/articles/131721.php
Scientists in the US examining how human melanoma, a deadly form of skin cancer, spreads in mice specially bred to be vulnerable to cancer, found that there was a higher proportion of tumor causing cells in cancerous tissue than had previously been assumed, overturning the "stem-cell" theory of cancer which proposes that a only a handful of specialized rogue cells is responsible for causing new tumors.

Scientists Probe Limits Of "Cancer Stem-Cell Model"
http://www.medicalnewstoday.com/articles/131717.php
One of the most promising new ideas about the causes of cancer, known as the cancer stem-cell model, must be reassessed because it is based largely on evidence from a laboratory test that is surprisingly flawed when applied to some cancers, University of Michigan researchers have concluded.

U.S. FDA Grants Orphan Drug Designation For Burzynski Research Institute's Antineoplaston Treatment For Gliomas
http://www.medicalnewstoday.com/articles/131693.php
The Burzynski Research Institute, Inc. (BRI) today announced that its antineoplaston A10 and antineoplaston AS2-1 therapy (ANP) has been granted orphan drug designation by the U.S. Food and Drug Administration ("FDA") for the treatment of gliomas.

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** CERVICAL CANCER / HPV VACCINE News **

Genetic Breakdown In Fanconi Anemia May Have Link To HPV-Associated Cancer
http://www.medicalnewstoday.com/articles/131831.php
A genetic malfunction that causes DNA instability in people with the blood disorder Fanconi anemia may put them at high risk for squamous cell carcinomas linked to human papillomavirus (HPV), according to a study posted online ahead of print by<i> Oncogene.

Hypersensitivity Reactions To The Quadrivalent HPV Vaccine Are Rare, British Medical Journal
http://www.medicalnewstoday.com/articles/131763.php
Hypersensitivity reactions to the quadrivalent HPV vaccine (4vHPV, Gardasil) are uncommon and most schoolgirls can tolerate subsequent doses, finds the first evaluation of the quadrivalent HPV vaccine published on <a href="http://www.

Women In Low-Income Areas Of England More Likely To Develop Cervical Cancer, Study Finds
http://www.medicalnewstoday.com/articles/131748.php
<BR>Women living in England's poorest areas are twice as likely as their counterparts in affluent regions to be diagnosed with cervical cancer, according to a study by the United Kingdom's <A href="http://www.

Study Finds Allergic Reactions Uncommon With HPV Vaccine Gardasil
http://www.medicalnewstoday.com/articles/131747.php
<BR>Allergic reactions to <A href="http://www.merck.com/" target=_new>Merck</A>'s human papillomavirus vaccine Gardasil are uncommon, and most girls and young women can tolerate further doses in the three-dose regimen, according to a <A href="http://www.

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** COLORECTAL CANCER News **

Relevance Of Computer-Aided Detection (CAD) And Image Analysis Software In Early Colon Cancer Screening And Diagnosis
http://www.medicalnewstoday.com/articles/131727.php
Medicsight PLC, an industry leader in and principal developer of Computer-Aided Detection (CAD) and medical image analysis software today announced clinical results from a new study that demonstrated CAD significantly increased the sensitivity of readers in the detection of colorectal cancers in multi-row detector CT (MDCT) colonography (CTC).

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** LUNG CANCER News **

No news for this category today.

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** LYMPHOMA / LEUKEMIA News **

EpiCept Reports New Data On Benefits Of Maintenance Therapy With Ceplene(R) And Interleukin-2 For AML Patients At ASH Annual Meeting
http://www.medicalnewstoday.com/articles/131848.php
EpiCept Corporation (Nasdaq and OMX Nordic Exchange: EPCT) today announced that new data on the benefits of maintenance therapy with Ceplene&reg; (histamine dihydrochloride) and interleukin-2 (IL-2) for Acute Myeloid Leukemia (AML) patients in complete remission will be presented at the 50th American Society of Hematology (ASH) Annual Meeting being held December 6-9 at the Moscone Center in San Francisco.

Effects Of Childhood Cancer Treatment Increase Adult Survivors' Risk Of Osteoporosis
http://www.medicalnewstoday.com/articles/131833.php
Men who survived childhood leukemia treatment into adulthood were more likely to have low bone mineral density than other adults their age, putting them at risk of osteoporosis and bone fractures, according to a new study.

The Leukemia & Lymphoma Society And Memgen Announce New Chronic Lymphocytic Leukemia Clinical Trial
http://www.medicalnewstoday.com/articles/131701.php
The Leukemia & Lymphoma Society (LLS) and Memgen, LLC jointly announce the beginning of a new clinical trial of ISF35, a cancer vaccine, at the University of California, San Diego (UCSD). LLS is collaborating on this trial in the hopes that it will speed the development and approval of a novel approach aimed at treating patients with fludarabine refractory and/or 17p deleted chronic lymphocytic leukemia (CLL).

Genta Receives Complete Response Letter From FDA To Amended Application Of Genasense(R) In Patients With Chronic Lymphocytic Leukemia
http://www.medicalnewstoday.com/articles/131688.php
Genta Incorporated (OTCBB: GNTA.OB) today announced that the Company has received a complete response letter from the Office of Oncology Drug Products (OODP) at the Food and Drug Administration (FDA) regarding the Company's amended New Drug Application (NDA) for the use of Genasense&reg; plus chemotherapy in patients with chronic lymphocytic leukemia (CLL).

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** PROSTATE / PROSTATE CANCER News **

Montpellier Prostate Cancer Patient Becomes First Cancer Patient In France Treated With Varian's RapidArc&trade; Radiotherapy
http://www.medicalnewstoday.com/articles/131842.php
A 60-year-old prostate cancer patient from Montpellier has become the first person in France to be treated using RapidArc&trade; technology from Varian Medical Systems (NYSE:VAR) for fast and precise forms of intensity modulated radiotherapy (IMRT).

Testosterone Levels Reduced By Prostate Cancer Drug In As Little As 3 Days
http://www.medicalnewstoday.com/articles/131793.php
More than 95 per cent of men who took degarelix for prostate cancer saw their testosterone levels fall dramatically as early as three days after they started treatment, according to a paper in the December issue of<i> BJU International.

Isis Announces That OGX-011 Has Shown Overall Survival Advantage In Prostate Cancer Compared To Standard Therapy In A Randomized Phase 2 Study
http://www.medicalnewstoday.com/articles/131704.php
Isis Pharmaceuticals, Inc. (Nasdaq: ISIS) announced that OncoGenex Pharmaceuticals, Inc. provided positive survival results from a randomized Phase 2 clinical trial of OGX-011 in combination with docetaxel and prednisone ("the OGX-011 arm") compared to docetaxel and prednisone alone ("the control arm") for first-line treatment of metastatic castrate resistant prostate cancer.

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